PERSONAL AUTONOMY AS A KEY FACTOR OF HUMAN SELF-DETERMINATION

Self-regulation and the problem of human autonomy: does psychology need choice, self-determination, and will?

The term autonomy literally refers to regulation by the self. Its opposite, heteronomy, refers to controlled regulation, or regulation that occurs without self-endorsement. At a time when philosophers and economists are increasingly detailing the nature of autonomy and recognizing its social and practical significance, many psychologists are questioning the reality and import of autonomy and cl...

Self-Determination of Indigenous Peoples within the Human Rights Context: A Right to Autonomy?

Inflammation, a Key Factor in Cancer Ambush

Inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, UV radiation, stress and etc. Persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from T cells. These molecules (e.g. IL-6, TNF-&alpha, IL-1&beta and IL-17) are mostly pleiotropic cytokines i...

Intentional Interpretation of the Poetic Text as a Key to the Author’s Self-Concept

Author's self-concept within our meaning is the self-presentation of rhymes in the content-related structure and reveals itself in the context of intentional interpretation of the poetic text, i.e. decoding the subject-matter and ideology rooted in it, complex of imageries and symbolic components. Hitting a target in seeking the key to the author’s self-concept is undertaken through the c...

STAT3 as a Key Factor in Tumor Microenvironment and Cancer Stem Cell

Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...